Biosynthesis of active pharmaceuticals: β-lactam biosynthesis in filamentous fungi
نویسندگان
چکیده
منابع مشابه
Molecular Regulation of b-Lactam Biosynthesis in Filamentous Fungi
INTRODUCTION .......................................................................................................................................................547 GENERAL ASPECTS OF b-LACTAM COMPOUNDS........................................................................................548 BIOSYNTHESIS OF PENICILLINS AND CEPHALOSPORINS: AN OUTLINE.............................................
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The most commonly used beta-lactam antibiotics for the therapy of infectious diseases are penicillin and cephalosporin. Penicillin is produced as an end product by some fungi, most notably by Aspergillus (Emericella) nidulans and Penicillium chrysogenum. Cephalosporins are synthesized by both bacteria and fungi, e.g., by the fungus Acremonium chrysogenum (Cephalosporium acremonium). The biosynt...
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Penicillins and cephalosporins are β-lactam antibiotics widely used in human medicine. The biosynthesis of these compounds starts by the condensation of the amino acids L-α-aminoadipic acid, L-cysteine and L-valine to form the tripeptide δ-L-α-aminoadipyl-l-cysteinyl-D-valine catalysed by the non-ribosomal peptide 'ACV synthetase'. Subsequently, this tripeptide is cyclized to isopenicillin N th...
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Filamentous fungi are microorganisms of great biotechnological interest due to their ability to synthesize a variety of bioactive secondary metabolites including β-lactam antibiotics, such as penicillins and cephalosporins. Hydrophobic (with aromatic side chains) penicillins are only produced by fungi, mainly Penicillium chrysogenum and Aspergillus (Emericella) nidulans, whereas hydrophilic cep...
متن کاملCarotene biosynthesis in fungi.
Studies on Neurospora crassa and mutants of Phycomyces blakesleeanus have led to a reappraisal of a number of important aspects of carotene biosynthesis. Results obtained from structural investigations, from inhibitor studies and from the use of labelled substrates with carotenogenic extracts of fungal mutants are discussed in the contexts of the stereochemistry, isomerization and dehydrogenati...
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ژورنال
عنوان ژورنال: Biotechnology and Genetic Engineering Reviews
سال: 2010
ISSN: 0264-8725,2046-5556
DOI: 10.1080/02648725.2010.10648143